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Qingdao Fraken International Trading Co., Ltd.

Sodium Hyaluronate, Hyaluronic Acid, Cosmetic Grade Sodium Hyaluronate manufacturer / supplier in China, offering High Quality Food / Cosmetic Grade Hyaluronic Acid / Sodium Hyaluronate, GMP Certified 0.9% Saline Injection / Sodium Chloride Injection, Dextrose and Sodium Chloride Injection, Detrose Injection / Glucose Injection and so on.

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High Quality Food / Cosmetic Grade Hyaluronic Acid / Sodium Hyaluronate

Purchase Qty.:
(kg)
1-99 100+
FOB Unit Price: US $250 US $200
Purchase Qty. (kg) FOB Unit Price
1-99 US $250
100+ US $200
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Port: Qingdao, China
Production Capacity: 300mt/Year
Payment Terms: L/C, T/T, Western Union, Money Gram

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Basic Info
  • Model NO.: HA
  • Function: Moisturizer, Anti-Aging, Whitening/Lightening, Make-up, Medicine
  • Group: Middle-aged and Old
  • Quality Guarantee Period: Two Years
  • Color: White
  • Odor: Odorless
  • Usage: Skin
  • Form: Powder
  • Transport Package: 25kgs/Drum
  • Origin: China
  • Type: Makeup Sets
  • Main Ingredient: Sodium Hyaluronate
  • Certification: MSDS
  • Store Method: Normal Temperature
  • Grade: Food, Cosmetic, Injection, Eye Drop, etc.
  • Sample: Available
  • Used for: Women
  • Trademark: Fraken
  • Specification: pharma grade
  • HS Code: 391390000
Product Description
Hyaluronic Acid, also named Sodium hyaluronate, are as follows:
1. Food grade
2. Cosmetic grade
3. Injection grade
4. Eye drop grade
5. Sodium hyaluronate solution 1%
6.Medical Sodium Hyaluronate Gel

Introduction:
Hyaluronic acid(HA) is a straight chain macromolecular mucopolysaccharide composed of repeat disaccharide units of glucuronic acid and N-acetylglucosamin. It widely consists in the extracellular space of human and animal tissue, vitreum, umbilical cord, skin joints synovia and cockscomb, etc. The commercial HA is commonly a sodium salt, called sodium hyaluronate, habitually called hyaluronic acid. HA is a new biological at home and abroad. Its molecular weight is from several ten thousand to several million. It's aqueous solution has outstanding moisture keeping ability, high viscoelasticity and lubricity. It is widely used in cosmetics, pharmacy and health and beauty food.

High Quality Food / Cosmetic Grade Hyaluronic Acid / Sodium Hyaluronate
Flow Chart of HA Production
1.Raw materials
2.Sterilization
3.Fermentation
4.Filtration
5. Absorption
6. CPC Isolation
7. Ethanol precipitation
8. Dewatering
9. Drying
10.Packing:25kg/drum or as your request.

Food grade Sodium hyaluronate

Sodium hyaluronate, also known as hyaluronan, or HA, is a linear high molecular weight mucopolysaccharide composed by thousands of repeating disaccharide units of D-glucuronic acid and N-acetyl-D-glucosamine.

1. Physiological functions of HA

HA is a natural substance, which widely exists in human and animal bodies. With its unique physical and chemical properties, it has a variety of important physiological functions in our body. Like a molecular sponge, HA is able to retain water up to 500-1000 times of its own weight. It is one of the most hydrophilic molecules in nature which maintains skin elastic and lubricates the joints.

Ageing slows down the metabolism of cells, HA synthesis in our body is decreased. As a result, there is not enough water in the collagenous fiber and elastic fiber of the skin, thus wrinkles appear. Because of the loss of HA within the synovial fluid of joints, it can lead to osteoarthritis.

2. Oral absorption effect of HA

The synthesis and degradation of HA in the human body is a dynamic balanced process. Experiments have proven in animals and humans that oral administration HA can increase the precursors of HA in body and promote the synthesis of HA. Furthermore, it can repair the body's moisturizing system to reduce skin wrinkles, improve joint function and has many other anti-aging benefits.

3.Applications in health food

HA applied into the food industry was originally started in Japan and American, and has now been widely recognized by consumers. 

ItemStandard
AppearanceWhite powder
SolubilitySoluble in water, practically insoluble in acetone and in anhydrous ethanol.
Glucuronic AcidMin.44%
Sodium HyaluronateMin.91%
Appearance of SolutionA600nm≤ 0.01
Nucleic AcidA260nm≤ 0.5
pH6.0-7.5
Molecular Weight1.0-1.5 Million Daltons
Protein Max.0.1%
Loss on dryingMax.10%
Residue on IgnitionMax.20%
ChloridesMax.0.5%
IronMax.80ppm
Heavy metalMax.20ppm
ArsenicMax.2ppm
Nitrogen3.0-4.0%
Bacteria CountMax.10CFU/g
Molds & YeastMax.10CFU/g
Staphylococcus aureusNegative
Pseudomonas aeruginosaNegative
HemolysisNegative
Viable Hemolytical StreptococciNegative

Sodium Hyaluronate can support Sodium Hyaluronate levels in the body. It can help people have full energy and youthful vigor. Besides, oral Sodium Hyaluronate is useful in maintaining skin elasticity by moisturizing the skin from the dermis to epidermis. Sodium Hyaluronate is also an impressive pain reliever. It can help people ease the injury of joints, especially their knees.Sodium Hyaluronate along with other ingredients including collagen, vitamins, chondroitin sulfate, glucosamine, and plant extracts can make tablets, capsules and oral solution which are good for skin care and joints care.

Hyaluronic acid is a high molecular weight polysaccharide with D- glucuronic acid and N-acetyl-glucosamine as repeating structure unit. Because of the action of hydrogen bond between the monosaccharide in HA linear axle, HA molecular forms a rigid screw column structure in space. Strong hydrophilic properties exist due to the large amount of hydroxyl groups. Furthermore, HA has a special water binding function and binds its water very strongly, so that it has strong water retention. Theoretically its binding water capacity is up to 500 ml/g as an ideal natural moisturizing factor.
HA is also one important component of the skin. It can prevent skin from aging and improve the appearance and tactile sensation of skin.
A part of low molecular weight HA can penetrate into dermal layer to control the mid-metabolism, and make the skin moist, smooth and elastic. Therefore the cosmetic functions of HA are its resistance against skin wrinkles and its general health protection. HA is not only a good skin moisturizer, but also promotes cell' s metabolism of skin. So HA stands for bio-mimetic cosmetics. The content of hyaluronic acid in body will decrease as they are aging, oral hyaluronic acid supplementation can supplement HA in body and improve skin conditions, moisturizing skin from the inside out, smoothing out wrinkles during cell metabolism. Oral hyaluronic acid Supplementation is very popular in Japan, USA and other western countries.
Hyaluronic acid is a natural part of the human body why it is highly suitable for many applications within the field of medicine and related aids. It is used in ophthalmology, orthopedics and cosmetic surgery. With the researching and development of application in medicine area, hyaluronic acid's application as HA-supplementation and medical treatment material will be one major stream in health care Industry.

Food Grade Hyaluronic Acid is manufactured through fermentation with streptococcus equi, subsp. Zooepidemicus. The raw materials used are non-animal sourced, non-GMO, and pose no BSE/TSE risk. Our production is strictly managed according to ISO 9001 and GMP standards and is Kosher and Halal certified.
Academic research indicates that dietary supplementation of Hyaluronic acid improves joint and skin health. Our Food Grade Hyaluronic Acid can be added to ordinary foods and beverages.

Specification: 
ItemStandard
AppearanceWhite powder
SolubilitySoluble in water, practically insoluble in acetone and in anhydrous ethanol.
Glucuronic AcidMin.44%
Sodium HyaluronateMin.91%
Appearance of SolutionA600nm≤ 0.01
Nucleic AcidA260nm≤ 0.5
pH6.0-7.5
Molecular Weight1.0-1.5 Million Daltons
ProteinMax.0.1%
Loss on dryingMax.10%
Residue on IgnitionMax.20%
ChloridesMax.0.5%
IronMax.80ppm
Heavy metalMax.20ppm
ArsenicMax.2ppm
Nitrogen3.0-4.0%
Bacteria CountMax.10CFU/g
Molds & YeastMax.10CFU/g
Staphylococcus aureusNegative
Pseudomonas aeruginosaNegative
HemolysisNegative
Viable Hemolytical StreptococciNegative
 
Item No.Molecular weight
HAF-N200K Da - 600K Da
HAF-H≥1,800K Da
HAF-M1,000K Da - 1,800K Da
HAF-L10K Da - 1,000K Da
HAF-Oligo<10K Da
Applications: Used in food or health product as a dietary supplement

Product Features:
Original bacteria name: Streptococcus Zooepidemicus
Made by fermentation

Molecular Weight (Dalton):
1. LWM: 2000 - 100,000 Dalton
2. Medium MW: 0.8 - 1.6 * 106 Dalton
3. High MW: > 2.0 * 106 Dalton
Details:
Usage Scope: Active ingredient for joint care and skin beauty etc.
Package: 100g/bottle. 1kg/foil-bag. 10kg/drum.20kg/drum.

Application:
Application formsFunction
Common food: beverage, jelly, dairy products, etc
Health food: usually in combination with Collagen, Vitamins, hondroitin Sulphate, or Glucosamine to make tablets, capsules or oral liquid
Restore skin moisture, improve skin health condition
Antioxidation 
Increase bone density and improve joint function
Improve bowel function and protect gastric mucosa


Shelf life:
Product in powder or granular form should be 24 months.
1%solution should be 12 months.

Since hyaluronic acid occurs naturally in the body, taking small amounts should be of no health concern. Hyaluronic acid based products are considered highly safe, HA is manufactured by fermentation with the strain of Streptococcus Zooepidemicus, a method widely used in the world. The raw material used in the fermentation are all derived from non-animal sources.
A series of safety experiments had been carried out, including acute toxicity test, three genetic toxicity tests, 90 days feeding test and teratogenicity test. All the results show that HA is an innocuous substance of high safety.

Chondroitin:
A. Chondroitin sulphate bovine
B. Chondroitin sulphate porcine
C. Chondroitin sulphate shark
D. Chondroitin sulphate chicken

Shark cartilage powder
Shark cartilage extract

Chondroitin tablet

Packing: 25kg/drum or as your request.
Shelf Life: The shelf life is 24 months in the original packing. And the temperature is not exceeding 25° C. Far away water and heat.
Delivery: Within two weeks after receiving your prepayment.

High Quality Food / Cosmetic Grade Hyaluronic Acid / Sodium Hyaluronate
 
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