Hyaluronic Acid, also named
Sodium hyaluronate, are as follows:
1. Food grade
2. Cosmetic grade
3. Injection grade
4. Eye drop grade
5. Sodium hyaluronate solution 1%
6. Medical Sodium Hyaluronate Gel
7. Fullerene sodium hyaluronate solution
Introduction:
Hyaluronic acid(HA) is a straight chain macromolecular mucopolysaccharide composed of repeat disaccharide units of glucuronic acid and N-acetylglucosamin. It widely consists in the extracellular space of human and animal tissue, vitreum, umbilical cord, skin joints synovia and cockscomb, etc. The commercial HA is commonly a sodium salt, called sodium hyaluronate, habitually called hyaluronic acid. HA is a new biological at home and abroad. Its molecular weight is from several ten thousand to several million. It's aqueous solution has outstanding moisture keeping ability, high viscoelasticity and lubricity. It is widely used in cosmetics, pharmacy and health and beauty food.
Flow Chart of HA Production
1.Raw materials
2.Sterilization
3.Fermentation
4.Filtration
5. Absorption
6. CPC Isolation
7. Ethanol precipitation
8. Dewatering
9. Drying
10.Packing:25kg/drum or as your request.
Food grade Sodium hyaluronate
Sodium hyaluronate, also known as hyaluronan, or HA, is a linear high molecular weight mucopolysaccharide composed by thousands of repeating disaccharide units of D-glucuronic acid and N-acetyl-D-glucosamine.
1. Physiological functions of HA
HA is a natural substance, which widely exists in human and animal bodies. With its unique physical and chemical properties, it has a variety of important physiological functions in our body. Like a molecular sponge, HA is able to retain water up to 500-1000 times of its own weight. It is one of the most hydrophilic molecules in nature which maintains skin elastic and lubricates the joints.
Ageing slows down the metabolism of cells, HA synthesis in our body is decreased. As a result, there is not enough water in the collagenous fiber and elastic fiber of the skin, thus wrinkles appear. Because of the loss of HA within the synovial fluid of joints, it can lead to osteoarthritis.
2. Oral absorption effect of HA
The synthesis and degradation of HA in the human body is a dynamic balanced process. Experiments have proven in animals and humans that oral administration HA can increase the precursors of HA in body and promote the synthesis of HA. Furthermore, it can repair the body's moisturizing system to reduce skin wrinkles, improve joint function and has many other anti-aging benefits.
3.Applications in health food
HA applied into the food industry was originally started in Japan and American, and has now been widely recognized by consumers.
| Item |
Standard |
| Appearance |
White powder |
| Solubility |
Soluble in water, practically insoluble in acetone and in anhydrous ethanol. |
| Glucuronic Acid |
Min.44% |
| Sodium Hyaluronate |
Min.91% |
| Appearance of Solution |
A600nm≤ 0.01 |
| Nucleic Acid |
A260nm≤ 0.5 |
| pH |
6.0-7.5 |
| Molecular Weight |
1.0-1.5 Million Daltons |
| Protein |
Max.0.1% |
| Loss on drying |
Max.10% |
| Residue on Ignition |
Max.20% |
| Chlorides |
Max.0.5% |
| Iron |
Max.80ppm |
| Heavy metal |
Max.20ppm |
| Arsenic |
Max.2ppm |
| Nitrogen |
3.0-4.0% |
| Bacteria Count |
Max.10CFU/g |
| Molds & Yeast |
Max.10CFU/g |
| Staphylococcus aureus |
Negative |
| Pseudomonas aeruginosa |
Negative |
| Hemolysis |
Negative |
| Viable Hemolytical Streptococci |
Negative |
Sodium Hyaluronate can support Sodium Hyaluronate levels in the body. It can help people have full energy and youthful vigor. Besides, oral Sodium Hyaluronate is useful in maintaining skin elasticity by moisturizing the skin from the dermis to epidermis. Sodium Hyaluronate is also an impressive pain reliever. It can help people ease the injury of joints, especially their knees.Sodium Hyaluronate along with other ingredients including collagen, vitamins, chondroitin sulfate, glucosamine, and plant extracts can make tablets, capsules and oral solution which are good for skin care and joints care.
Hyaluronic acid is a high molecular weight polysaccharide with D- glucuronic acid and N-acetyl-glucosamine as repeating structure unit. Because of the action of hydrogen bond between the monosaccharide in HA linear axle, HA molecular forms a rigid screw column structure in space. Strong hydrophilic properties exist due to the large amount of hydroxyl groups. Furthermore, HA has a special water binding function and binds its water very strongly, so that it has strong water retention. Theoretically its binding water capacity is up to 500 ml/g as an ideal natural moisturizing factor.
HA is also one important component of the skin. It can prevent skin from aging and improve the appearance and tactile sensation of skin.
A part of low molecular weight HA can penetrate into dermal layer to control the mid-metabolism, and make the skin moist, smooth and elastic. Therefore the cosmetic functions of HA are its resistance against skin wrinkles and its general health protection. HA is not only a good skin moisturizer, but also promotes cell' s metabolism of skin. So HA stands for bio-mimetic cosmetics. The content of hyaluronic acid in body will decrease as they are aging, oral hyaluronic acid supplementation can supplement HA in body and improve skin conditions, moisturizing skin from the inside out, smoothing out wrinkles during cell metabolism. Oral hyaluronic acid Supplementation is very popular in Japan, USA and other western countries.
Hyaluronic acid is a natural part of the human body why it is highly suitable for many applications within the field of medicine and related aids. It is used in ophthalmology, orthopedics and cosmetic surgery. With the researching and development of application in medicine area, hyaluronic acid's application as HA-supplementation and medical treatment material will be one major stream in health care Industry.
Food Grade Hyaluronic Acid is manufactured through fermentation with streptococcus equi, subsp. Zooepidemicus. The raw materials used are non-animal sourced, non-GMO, and pose no BSE/TSE risk. Our production is strictly managed according to ISO 9001 and GMP standards and is Kosher and Halal certified.
Academic research indicates that dietary supplementation of Hyaluronic acid improves joint and skin health. Our Food Grade Hyaluronic Acid can be added to ordinary foods and beverages.
Specification:
| Item |
Standard |
| Appearance |
White powder |
| Solubility |
Soluble in water, practically insoluble in acetone and in anhydrous ethanol. |
| Glucuronic Acid |
Min.44% |
| Sodium Hyaluronate |
Min.91% |
| Appearance of Solution |
A600nm≤ 0.01 |
| Nucleic Acid |
A260nm≤ 0.5 |
| pH |
6.0-7.5 |
| Molecular Weight |
1.0-1.5 Million Daltons |
| Protein |
Max.0.1% |
| Loss on drying |
Max.10% |
| Residue on Ignition |
Max.20% |
| Chlorides |
Max.0.5% |
| Iron |
Max.80ppm |
| Heavy metal |
Max.20ppm |
| Arsenic |
Max.2ppm |
| Nitrogen |
3.0-4.0% |
| Bacteria Count |
Max.10CFU/g |
| Molds & Yeast |
Max.10CFU/g |
| Staphylococcus aureus |
Negative |
| Pseudomonas aeruginosa |
Negative |
| Hemolysis |
Negative |
| Viable Hemolytical Streptococci |
Negative |
| Item No. |
Molecular weight |
| HAF-N |
200K Da - 600K Da |
| HAF-H |
≥1,800K Da |
| HAF-M |
1,000K Da - 1,800K Da |
| HAF-L |
10K Da - 1,000K Da |
| HAF-Oligo |
<10K Da |
| Applications: Used in food or health product as a dietary supplement |
Product Features:
Original bacteria name: Streptococcus Zooepidemicus
Made by fermentation
Molecular Weight (Dalton):
1. LWM: 2000 - 100,000 Dalton
2. Medium MW: 0.8 - 1.6 * 106 Dalton
3. High MW: > 2.0 * 106 Dalton
Details:
Usage Scope: Active ingredient for joint care and skin beauty etc.
Package: 100g/bottle. 1kg/foil-bag. 10kg/drum.20kg/drum.
Application:
| Application forms |
Function |
Common food: beverage, jelly, dairy products, etc
Health food: usually in combination with Collagen, Vitamins, hondroitin Sulphate, or Glucosamine to make tablets, capsules or oral liquid |
Restore skin moisture, improve skin health condition
Antioxidation
Increase bone density and improve joint function
Improve bowel function and protect gastric mucosa |
Shelf life:
Product in powder or granular form should be 24 months.
1%solution should be 12 months.
Since hyaluronic acid occurs naturally in the body, taking small amounts should be of no health concern. Hyaluronic acid based products are considered highly safe, HA is manufactured by fermentation with the strain of Streptococcus Zooepidemicus, a method widely used in the world. The raw material used in the fermentation are all derived from non-animal sources.
A series of safety experiments had been carried out, including acute toxicity test, three genetic toxicity tests, 90 days feeding test and teratogenicity test. All the results show that HA is an innocuous substance of high safety.
Chondroitin:
A. Chondroitin sulphate bovine
B. Chondroitin sulphate porcine
C. Chondroitin sulphate shark
D. Chondroitin sulphate chicken
Shark cartilage powder
Shark cartilage extract
Chondroitin tablet
Packing: 25kg/drum or as your request.
Shelf Life: The shelf life is 24 months in the original packing. And the temperature is not exceeding 25° C. Far away water and heat.
Delivery: Within two weeks after receiving your prepayment.
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To get more information, just feel free to contact with us. Thanks.
Mr. Liu
Qingdao fraken international trading Co., Ltd
Address: RM1005 post mansion yan'an three road, qingdao, China
Web: http://fraken.en.made-in-china.com
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