Natamycin, also named Pimaricin
1. Content: 90%, 95%
2. Specification: USP, FCC
3. Function: Preservative
4. Packing: 100g x 50 bottles / carton.
500g x20 bottles / carton.
1000g x 10 bottles / carton.
Natamycin products:
Natamycin 50% Lactose
Natamycin 50% Dextrose
Natamycin 50% NaCl (sodium chloride)
Natamycin 95%
Appearance: Cream-colored to slightly yellow powder
Natamycin (pimaricin) is a tetraene polyene antibiotic derived from Streptomyces natalensis. The antibiotic is a very strong anti-fungal reagents, It can effectively inhibit the growth of yeast and mold and prevent the aflatoxin formation of filamentous fungi. Compared with other antibacterial ingredients, natamycin has very low toxicity to the cells of mammals.
It can be widely applied to the diseases caused by fungi.
Natamycin can inhibit fungi, it can be applied to cure diseases caused by fungal such as eye drops, gynecological suppository and skin cream.
| Items |
Specification |
| Appearance |
white to yellow powder |
| Identification |
meet the USP29 standard |
| Assay(dry basis) |
90-102% |
| Crystallinity |
meet the USP29 standard |
| Water |
6.0-9.0% |
| Ph |
5.0-7.5 |
| Ash |
≤0.5% |
| Heavy metals |
≤10ppm |
| Lead |
≤2ppm |
| Arsenic |
≤3ppm |
| Mercury |
≤1ppm |
| Total plate count |
≤100cfu/g |
| Coliform |
≤40MPN/100g |
| Salmonella |
negative in 25g |
| Listeria monocyt |
negative in 25g |
| Conclusion: |
USP29 and FCC IV |
Storage:
Sealed keeping in cool place where there is no direct sunshine exposure and the temperature is below 20° C, the validity period is two years.
Advantage
(1)To prolong the shelf life of food treated.
(2)Very low dosage.
(3)Natamycin does not affect the flavor of foods
(4)Natamycin will not penetrate into the food, only be on the surface of food when it was used on the surface of food.
(5)Natamycin can be used under the condition of wide range of pH value
(6)To inhibit the fungi toxin
Natamycin is a natural antifungal agent that belongs to the group of polyene macrolide produced by Streptomyces natalensis. Natamycin is a crystallized substance that is colorless, odorless and tasteless. Natamycin is very stable so that it can be widely applied in the food industry for more than 30 years.
Characteristics
ØNomenclature
•International Nonproprietary Name (INN):Natamycin
•Compendial name: Natamycin
•Other synonym: Pimaricin
•Molecular formula: C33H47NO13
•Relative molecular mass: 665.73
•Company's code: NTA
•Chemical Abstracts Service (CAS) registry number: 7681-93-8
ØPhysico-chemical properties
•White to creamy-white, almost odourless, crystalline powder
•Practically insoluble in water, lipid and mineral oils
•Slightly soluble in methanol; soluble in glacial acetic acid
•Non-sterile micronized or non-micronized
ØBiological properties
•Natamycinis active against yeast and moulds, but not bacteria, virus, and other organisms like protozoa.
•Natamycin isthemost effective at pH levels of between 5 and 7while the fungicide'seffectiveness may be reduced by as much as 30% at below pH 4 and above pH 9.
Compliance with Pharmacopoeia and Official Standards
We regularly supplies both active ingredient of natamycinand formulated form of natamycin (mainly 50%) to comply with customers' needs. However, the company can supply a highly pure product of natamycin, of which contentis more than 98%.
ØActive ingredient of Natamycinconforms to US Pharmacopoeia 39
•Content of natamycin (drybasis): 90.0%-102.0%
•pH: 5.0-7.5
•Water: 6.0%-9.0%
ØActive ingredient of Natamycinconforms to ECDirective 2008/84/EC
•Content of natamycin (drybasis): ≥95.0%
•pH: 5.5-7.5
•Loss on drying: ≤ 8.0%
•Specific rotation: +250-+295(1% w/v solution in glacial acetic acid)
•Sulfated ash: ≤ 0.5%
•Arsenic: ≤ 3mg/kg
•Lead: ≤ 5mg/kg
ØActive ingredient of Natamycinconforms to ECDirective 2008/84/EC(Continued)
•Mercury: ≤ 1mg/kg
•Heavy metal (as Pb): ≤ 10mg/kg
•Total viable count: ≤ 100cfu/g
ØEnd-Use Formulated Natamycinwith Glucose, Lactose, or Sodium Chloride
•Content of natamycin: 50%-55%
•pH: 5.0-7.5
•Loss on drying: ≤ 8.0%
•Total viable count: ≤ 100cfu/g
Indication and Application
ØNatamycin has been used as a natural food preservative for more than 30 years dueto its fungicidal activity against almost all fungi and yeasts. In addition, as natamycin has no antibacterial action, it does not interfere with the food's natural maturing processes.
ØNatamycin can be applied on the surface of cheeses or cured meat productsby dipping the product in an aqueous solution of natamycin, or by spraying the aqueous solution around the product. The most common concentration varies between 1,000 and 2,000 ppm.
ØFor agricultural use (bio-pesticide), natamycin is also used tocontrol dry bubble disease caused by Verticillium fungicolain mushroom production facilities.
Regulatory Compliances
Following documents and certificates are available as requested;
ØEU Drug Master File (DMF) with full impurity profile complies with EMA requirements
ØCertificates of KOSHER, HALAL, ISO9001, ISO22000, ISO14001, and OHSAS18001
Availability
ØNon-sterile active ingredient of natamycin(micronized/non-micronized) complieswith USP 39 (purity, 90.0%-102.0%), and EC Directive 2008/84/EC (purity, ≥95.0%) is available, respectively.
Ø50% end-use formulations of natamycin with different excipients (Glucose, Lactose, Sodium chloride) are also available. Package sizes of the end-sue for mulations are 100g×50 bottles/carton, 500g×10 bottles/carton, and 10 kg/drum, respectively.
We also have Nisin 1000IU/mg.
1. Nisin
A. Food grade
B. Content: 1000IU/mg min
C. CAS: 1414-45-5
2. Natamycin, also named Pimaricin
A. Food grade 50% min glucose, lactose & NaCl
B. Pharma grade 90% min
3. Polylysine
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To get more information, just feel free to contact with us. Thanks.
Mr. Liu
Qingdao Fraken International Trading Co., Ltd
Address: RM1005 post mansion yan'an three road, Qingdao, China
Web: http://fraken.en.made-in-china.com
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