High Quality Diosmin / Hesperidin (9: 1) & Ep Diosmin

• Customization: Available
• Certification: ISO, GMP
• Assay Method: GPC, HPLC, UV
• Model NO.: DSM
• Application Form: Lotion, Paste, Tablet, Capsule
• Application: Food, Health Care Products, Medicine
• State: Powder
• Extract Source: Citrus Aurantium
• Source: Citrus Aurantium
• Form: Powder
• Packaging Material: Paper
• Storage Method: Normal
• Extraction Process: Chemical
• Raw Material: Plants
• Transport Package: 25kgs/Drum
• Specification: EP
• Trademark: Fraken
• Origin: China
• HS Code: 29322000
• Production Capacity: 1, 000mt Per Year

Product Description

Diosmin
CAS: 520-27-4
Specification: 90%, 95%, EP6, Diosmin/Hesperidin(90/10)Micronized product (5um or 10um)
Origin: Hesperidin is extracted from dried fruit of citrus aurantium and its derivates
Function: Diosmin is the semi-synthesis product of Hesperidin, which used in treating the chronic venous insufficiency and acute naevus. It is also a new potential anticancer API

Diosmin is a semisynthetic drug (modified hesperidin), a member of the flavonoid family. It is an oral phlebotropic drug used in the treatment of venous disease, i. E., chronic venous insufficiency (CVI) and hemorrhoidal disease (HD), in acute or chronic hemorrhoids, in place of rubber-band ligation, in combination with fiber supplement, or as an adjuvant therapy to hemorrhoidectomy, in order to reduce secondary bleeding. To control internal symptoms of hemorrhoids (piles), it is used with hesperidin.
Clinical studies have been inconclusive and no review articles on its use in vascular disease have been published.

Specification:

Analysis	Specification	Results
Diosmin	90.0%	90.8%
Physical & Chemical Control
Identification	The infrared absorption spectrophotometry of the product is same as the infraredabsorption spectrophotometry of Diosmin CRS	Comform
Appearance	Greyish-yellow or light yellotometry of ow hygroscopic powder	Comform
Solubility	Practically insoluble in water, soluble in dimethyl sulphoxide, practically insoluble in alcohol. It dissolves in dilute solutions of alkali hydroxides.	Comform
Odor	Characteristic	Comform
Mesh Size	100% pass 80 mesh	Comform
- iodine	≤ 0.1%	Comform
Pyridine	≤ 200 ppm	66 ppm
- impurity A (acetoisovanillone)	≤ 1.0 %	0.00%
- impurity B (hesperidin)	≤ 5.0 %	0.30%
- impurity C (isorhoifolin)	≤ 3.0 %	2.76%
- impurity E (linarin)	≤ 3.0 %	2.72%
- impurity F(diosmetin)	≤ 3.0 %	0.24%
- any other impurity	≤ 1.0 %	0.68%
- total of other impurities and impurity a	≤ 1.0 %	0.68%
- total	≤ 10.0 %	6.70%
Heavy metals	≤ 20 ppm	Conform
water (KF)	≤6 %	2.96%
Microbiological
Total Plate Count	<1000cfu/g	160cfu/g
Yeast & Mold	<100cuf/g	10cfu/g
Salmonella	Negative	Negative
E. Coli	Negative in 1g	Negative in 1g

Diosmin/Hesperidin 9:1 combination for hemorrhoids, varicose veins
Specification Diosmin/Hesperidin 9: 1
CAS520-27-4,
Molecular formula: C28H32O15,
Combination ingredients spec: Diosmin 90%, 92%, 95%, hesperidin 90%, hesperidin 92%, hesperidin 95%
Annual output100 tons
Package25kg/drum
Applied industries: Dietary supplement, drugs
Main benefits: Cure hemorrhoids, varicose veins, veins of the legs
Other names: Sweet oranges (Citrus sinensis), DiosVein,

Diosmin and hesperidin is a great combination for vein disorders, such as hemorrhoids, varicose veins, etc. Diosmin has the necessary benefits from the combination, but it works much better together with hesperidin. Moreover, diosmin/hesperidin with the proportion 9: 1 or 90: 10 are the best formula after numerous experiments and proofs, some other formulas also include Horse chestnut (Aesculus hippocastanum) seed extract, Butcher's Broom Extract (Ruscus aculeatus) (rhizome) (10% ruscogenins), Gotu kola (Centella asiatica) whole plant extract (min 40% asiaticosides), etc. All these ingredients except diosmin and hesperidin are to achieve the best wanted effects. The most common specification for this combination from our clients is diosmin 90% and hesperidin 10%.

The main benefits of Diosmin/Hesperidin 9: 1
Diosmin/Hesperidin is the perfect combination for healthy leg veins. This unique natural formula combines two powerful antioxidant flavonoids to promote healthy blood flow in the legs and throughout the body. This combination is good to the veins of the legs. Veins in legs are a problem for many middle or elder age men.

Hesperidin 90%, 95%, 98% HPLC
Hesperidin is a flavonoid found in the rinds of citrus fruits, which is one of the flavonoids that give citrus fruits their color and taste. Along with the compound rutin, hesperidin is the most active bioflavonoid in citrus based fruits. The hesperidin bioflavonoid helps protect your body from conditions like cancer, circulatory problems and heart disease. As a citrus bioflavonoid, hesperidin facilitates the formation of vitamin C complex, which supports healthy immune system functions.
Hesperidin is also referred to by names like bioflavonoid, citrus bioflavonoid, and hesperin methyl-chalcone. It is often present in multi-vitamins, though it can also be found as a pure extract. You can get hesperidin in certain foods or as a dietary supplement. While hesperidin and other similar bioflavonoids are commonly referred to as vitamin P, they are not actual vitamins. Hesperidin does not naturally occur in the body; You can only get it through foods or synthetic supplements. Before using a hesperidin supplement, consult your physician to determine its safety for your health conditions,

Service we can provide:
1. Mixed container, we can mix different items in one container.
2. Quality control, before shipment, free sample for test. After shipment, keep sample for 3 years
3. Prompt shipment with professional documents
4. Packing as your request, with photo before shipment

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To get more information, just feel free to contact with us. Thanks.
Mr. Liu
Qingdao Fraken International Trading Co., Ltd
Address: RM1005 post mansion yan'an three road, Qingdao, China 
Web: http://fraken.en.made-in-china.com/