| Customization: | Available |
|---|---|
| Function: | Antipyretic Analgesic and Non-Steroidal Anti-Inflammatory Analgesic |
| Certification: | GMP |
|
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Paracetamol
Paracetamol (Acetaminophen)
Paracetamol DC
Paracetamol tablet
Paracetamol Injection 1ml: 150mg 2ml: 300mg
Other name: 4-Acetamidophenol; N-Acetyl-4-aminophenol; p-Hydroxyacetanilide
CAS NO.: 103-90-2
EINECS NO.: 203-157-5
FEMA: 2878
Molecular Formula: C8H9NO2
Molecular Weight: 151.16
InChI: 1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)
Melting point: 168-172ºC
Water solubility: 14G/L(20ºC)
Appearance: White or off white crystalline powder
Solubility:Soluble in ethanol, acetone and hot water, hardly soluble in water, insoluble in petroleum ether and benzene. No smell, taste bitter. Saturated water solution pH 5.5 to 6.5
Specification:99%min
Standard: EP/BP/USP
Odor: odorless
Paracetamol, also known as acetaminophen, chemically named N-acetyl-p-aminophenol, is a widely used over-the-counter analgesic (pain reliever) and antipyretic (fever reducer). Acetaminophen is the name adopted for this pharmacologic agent in the U. S. (USAN) and Japan; Paracetamol is approved in a variety of international venues (INN, AAN, BAN, etc. ).
Paracetamol is classified as a mild analgesic. It is commonly used for the relief of headaches and other minor aches and pains and is a major ingredient in numerous cold and flu remedies. In combination with opioid analgesics, paracetamol can also be used in the management of more severe pain such as post-surgical pain and providing palliative care in advanced cancer patients. Though paracetamol is used to treat inflammatory pain, it is not generally classified as an NSAID because it exhibits only weak anti-inflammatory activity.
Specification:
|
Tests |
Standards |
Results |
|
Appearance |
White or almost white ,crystalline powder. |
White,crystalline powder. |
|
Identification |
A:IR absorption |
Complies |
|
B:UV absorption |
Complies |
|
|
C:TLC |
Complies |
|
|
Melting point |
168~172°C |
169.0~170.9°C |
|
Water |
Not more than0.5% |
0.08% |
|
Related substance |
Impurity(chloroacetanilide)not more than 10 ppm |
2ppm |
|
Impurity K(4-aminophenol)not more than 50 ppm |
15 ppm |
|
|
Impurity F(4-nitrophenol)not more than 0.05% |
Not detected |
|
|
any other impurity not more than 0.05% |
0.01% |
|
|
Total of other impurities not more than 0.1% |
0.02% |
|
|
Residue on ignition |
Not more than 0.1% |
0.05% |
|
Chloride |
Not more than 0.014% |
Less than 0.014% |
|
Sulfate |
Not more than 0.02% |
Less than 0.02% |
|
Sulfide |
Conforms |
Conforms |
|
Heavy metals |
Not more than 0.001% |
Less than 0.001% |
|
Free p-aminophenol |
Not more than 0.005% |
Less than 0.005% |
|
Limit of P-chloroacetanilide |
Not more than 0.001% |
Less than 0.001% |
|
Readily carbonizable substances |
Conforms |
Conforms |
|
Residual solvents |
Residual content of acetic acid is limited by the test of loss on dryingnot more than0.5% |
0.08% |
|
Assay(anhydrous basis) |
99.0~101.0% |
99.6% |
|
Conclusion: Complies with USP34/ BP2011 |
||
Aspirin
Aspirin / Acetylsalicylic Acid: CP/BP/USP/EP
Acetylsalicylic Acid DC90
Sodium salicylate BP
Medical Salicylic Acid CP/BP/USP
Salicylamide USP/JP
Aspirin tablet
Aspirin, also known as acetylsalicylic acid, is a salicylate drug, often used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication. Aspirin also has an antiplatelet effect by inhibiting the production of thromboxane, which under normal circumstances binds platelet molecules together to create a patch over damaged walls of blood vessels. Because the platelet patch can become too large and also block blood flow, locally and downstream, aspirin is also used long-term, at low doses, to help prevent heart attacks, strokes, and blood clot formation in people at high risk of developing blood clots. It has also been established that low doses of aspirin may be given immediately after a heart attack to reduce the risk of another heart attack or of the death of cardiac tissue. Aspirin may be effective at preventing certain types of cancer, particularly colorectal cancer.
Physical and Chemical Properties: White crystal or crystalline powder,with acid taste and is stable in dry air,slowly hydrolyze into salicylic acid and acetic anhydride.Its solution shows and acid reaction.Sparingly soluble in alcohol,chloroform or ether,slightly soluble in water or absolute ether,it dissolves in alkali hydroxide or alkali carbonate solution and decomposes at the same time.
Molecular Formula:C9H7O4
Molecular Weight:179.15
CAS Registry Number:50-78-2
EINECS:200-064-1
Quality:CP/BP/USP
Melting point:136-140°C
Boiling point:321.4°C at 760 mmHg
Flash point:131.1°C
Water solubility:3.3 g/L (20°C)
Vapour Pressur:0.000124mmHg at 25°C
InChI: 1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)
Synonyms: 2-Acetoxybenzoic acid
Density:1.35
Specifications:
| Item | Standard | ||||
| Appearance | white crystalline powder | ||||
| Clarity and Color of Solution |
clear and colorless | ||||
| Heavy metals | 20ppm max | ||||
| Salicylic acid | 0.05% max | ||||
| Related substances | 0.25%max | ||||
| Loss on drying | 0.5% max | ||||
| Sulphated ash | 0.1%max | ||||
| Assay | 99.5%~101% | ||||
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